Outbreak of Chikungunya on Reunion Island: Early Clinical and Laboratory Features in 157 Adult Patients
Identifieur interne : 000285 ( France/Analysis ); précédent : 000284; suivant : 000286Outbreak of Chikungunya on Reunion Island: Early Clinical and Laboratory Features in 157 Adult Patients
Auteurs : Gianandrea Borgherini [France] ; Patrice Poubeau [France] ; Frederik Staikowsky [France] ; Manuella Lory [France] ; Nathalie Le Moullec [France] ; Jean Philippe Becquart [France] ; Catherine Wengling [France] ; Alain Michault [France] ; Fabrice Paganin [France]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2007.
Abstract
Background. Chikungunya is a reemerging disease. In 2005–2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period. Methods. Adult patients with acute chikungunya (defined as onset of fever and/or polyarthralgia in the 5 days preceding consultation) and laboratory-confirmed chikungunya who were referred to Groupe Hospitalier Sud Reunion during the period from March 2005 through April 2006 were included in this retrospective study. Their clinical and laboratory features are reported. Results. Laboratory-confirmed acute chikungunya was documented in 157 patients. The mean age of patients was 57.9 years, and the ratio of male to female patients was 1.24 : 1. Sixty percent of patients had at least 1 comorbidity. Ninety-seven patients (61.8%) were hospitalized, and 60 (38.2%) were treated as outpatients. Five fatalities were reported. One hundred fifty-one patients (96.1%) experienced polyarthralgia, and 129 (89%) experienced fever. Gastrointestinal symptoms were reported by 74 patients (47.1%), and skin rash was reported by 63 (40.1%). Hemorrhagic signs were rare. Lymphopenia and hypocalcemia were the prominent laboratory findings. Severe thrombocytopenia was rarely observed. Conclusions. Chikungunya virus can be responsible for explosive outbreaks of disease. Polyarthralgia and fever are the 2 main clinical features. In this era of travel and globalization, chikungunya should be considered in the differential diagnosis of febrile polyarthralgia with an abrupt onset.
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DOI: 10.1086/517537
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sortKey="Becquart, Jean Philippe" sort="Becquart, Jean Philippe" uniqKey="Becquart J" first="Jean Philippe" last="Becquart">Jean Philippe Becquart</name></author><author><name sortKey="Wengling, Catherine" sort="Wengling, Catherine" uniqKey="Wengling C" first="Catherine" last="Wengling">Catherine Wengling</name></author><author><name sortKey="Michault, Alain" sort="Michault, Alain" uniqKey="Michault A" first="Alain" last="Michault">Alain Michault</name></author><author><name sortKey="Paganin, Fabrice" sort="Paganin, Fabrice" uniqKey="Paganin F" first="Fabrice" last="Paganin">Fabrice Paganin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CFB04B855E574C0F7D30CA6B0CA8E43236FEA356</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1086/517537</idno><idno type="url">https://api.istex.fr/ark:/67375/HXZ-822ZKS17-6/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001925</idno><idno type="wicri:explorRef" 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xml:lang="fr">France</country><wicri:regionArea>Services de Pneumologie et Maladies Infectieuses, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">France</country><wicri:regionArea>Reprints or correspondence: Dr. Gianandrea Borgherini, Service de Pneumologie et Maladies Infectieuses, Groupe Hospitalier Sud Reunion, BP 350, 97448 Saint Pierre, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Poubeau, Patrice" sort="Poubeau, Patrice" uniqKey="Poubeau P" first="Patrice" last="Poubeau">Patrice Poubeau</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Services de Pneumologie et Maladies Infectieuses, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Staikowsky, Frederik" sort="Staikowsky, Frederik" uniqKey="Staikowsky F" first="Frederik" last="Staikowsky">Frederik Staikowsky</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Urgences, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Lory, Manuella" sort="Lory, Manuella" uniqKey="Lory M" first="Manuella" last="Lory">Manuella Lory</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Services de Pneumologie et Maladies Infectieuses, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Moullec, Nathalie Le" sort="Moullec, Nathalie Le" uniqKey="Moullec N" first="Nathalie Le" last="Moullec">Nathalie Le Moullec</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Endocrinologie, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Becquart, Jean Philippe" sort="Becquart, Jean Philippe" uniqKey="Becquart J" first="Jean Philippe" last="Becquart">Jean Philippe Becquart</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Gastro-enterologie, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Wengling, Catherine" sort="Wengling, Catherine" uniqKey="Wengling C" first="Catherine" last="Wengling">Catherine Wengling</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Medecine Interne, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Michault, Alain" sort="Michault, Alain" uniqKey="Michault A" first="Alain" last="Michault">Alain Michault</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Virologie, Groupe Hospitalier Sud Reunion, Saint Pierre, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author><author><name sortKey="Paganin, Fabrice" sort="Paganin, Fabrice" uniqKey="Paganin F" first="Fabrice" last="Paganin">Fabrice Paganin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Services de Pneumologie et Maladies Infectieuses, La Réunion</wicri:regionArea><wicri:noRegion>La Réunion</wicri:noRegion><wicri:noRegion>La Réunion</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2007</date><biblScope unit="vol">44</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1401">1401</biblScope><biblScope unit="page" to="1407">1407</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background. Chikungunya is a reemerging disease. In 2005–2006, a severe outbreak occurred on Reunion Island in the southwestern part of the Indian Ocean. Other islands in this area were affected during the same period. Methods. Adult patients with acute chikungunya (defined as onset of fever and/or polyarthralgia in the 5 days preceding consultation) and laboratory-confirmed chikungunya who were referred to Groupe Hospitalier Sud Reunion during the period from March 2005 through April 2006 were included in this retrospective study. Their clinical and laboratory features are reported. Results. Laboratory-confirmed acute chikungunya was documented in 157 patients. The mean age of patients was 57.9 years, and the ratio of male to female patients was 1.24 : 1. Sixty percent of patients had at least 1 comorbidity. Ninety-seven patients (61.8%) were hospitalized, and 60 (38.2%) were treated as outpatients. Five fatalities were reported. One hundred fifty-one patients (96.1%) experienced polyarthralgia, and 129 (89%) experienced fever. Gastrointestinal symptoms were reported by 74 patients (47.1%), and skin rash was reported by 63 (40.1%). Hemorrhagic signs were rare. Lymphopenia and hypocalcemia were the prominent laboratory findings. Severe thrombocytopenia was rarely observed. Conclusions. Chikungunya virus can be responsible for explosive outbreaks of disease. Polyarthralgia and fever are the 2 main clinical features. In this era of travel and globalization, chikungunya should be considered in the differential diagnosis of febrile polyarthralgia with an abrupt onset.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Borgherini, Gianandrea" sort="Borgherini, Gianandrea" uniqKey="Borgherini G" first="Gianandrea" last="Borgherini">Gianandrea Borgherini</name></noRegion><name sortKey="Becquart, Jean Philippe" sort="Becquart, Jean Philippe" uniqKey="Becquart J" first="Jean Philippe" last="Becquart">Jean Philippe Becquart</name><name sortKey="Borgherini, Gianandrea" sort="Borgherini, Gianandrea" uniqKey="Borgherini G" first="Gianandrea" last="Borgherini">Gianandrea Borgherini</name><name sortKey="Borgherini, Gianandrea" sort="Borgherini, Gianandrea" uniqKey="Borgherini G" first="Gianandrea" last="Borgherini">Gianandrea Borgherini</name><name sortKey="Lory, Manuella" sort="Lory, Manuella" uniqKey="Lory M" first="Manuella" last="Lory">Manuella Lory</name><name sortKey="Michault, Alain" sort="Michault, Alain" uniqKey="Michault A" first="Alain" last="Michault">Alain Michault</name><name sortKey="Moullec, Nathalie Le" sort="Moullec, Nathalie Le" uniqKey="Moullec N" first="Nathalie Le" last="Moullec">Nathalie Le Moullec</name><name sortKey="Paganin, Fabrice" sort="Paganin, Fabrice" uniqKey="Paganin F" first="Fabrice" last="Paganin">Fabrice Paganin</name><name sortKey="Poubeau, Patrice" sort="Poubeau, Patrice" uniqKey="Poubeau P" first="Patrice" last="Poubeau">Patrice Poubeau</name><name sortKey="Staikowsky, Frederik" sort="Staikowsky, Frederik" uniqKey="Staikowsky F" first="Frederik" last="Staikowsky">Frederik Staikowsky</name><name sortKey="Wengling, Catherine" sort="Wengling, Catherine" uniqKey="Wengling C" first="Catherine" last="Wengling">Catherine Wengling</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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